Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword.

نویسنده

  • Alberto Pugliese
چکیده

The Journal of Clinical Investigation | May 2003 | Volume 111 | Number 9 14. Abramsson, A., et al. 2002. Analysis of mural cell recruitment to tumor vessels. Circulation. 105:112–117. 15. Benjamin, L.E., Golijanin, D., Itin, A., Pode, D., and Keshet, E. 1999. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest. 103:159–165. 16. Simon, M.P., et al. 1997. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Nat. Genet. 15:95–98. 17. Pietras, K., et al. 2002. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res. 62:5476–5484. 18. Heuchel, R., et al. 1999. Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3′ kinase signaling. Proc. Natl. Acad. Sci. U. S. A. 96:11410–11415. 19. Coussens, L.M., and Werb, Z. 2002. Inflammation and cancer. Nature. 420:860–867. 20. Luttun, A., et al. 2002. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8:831–840. 21. Schoppmann, S.F., et al. 2002. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am. J. Pathol. 161:947–956 22. Yancolpoulos, G.D., et al. 2000. Vascular-specific growth factors and blood vessel formation. Nature. 407:242–248. 23. Olofsson, B., et al. 1998. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 95:11709–11714. 24. Bergsten, E., et al. 2001. PDGF-D is a specific, protease-activated ligand for the PDGF-β–receptor. Nat. Cell Biol. 3:512–516. 25. LaRochelle, W.J., et al. 2001. PDGF-D, a new protease-activated growth factor. Nat. Cell Biol. 3:517–521.

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عنوان ژورنال:
  • The Journal of clinical investigation

دوره 111 9  شماره 

صفحات  -

تاریخ انتشار 2003